Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health:


Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and modulate inflammatory processes. They also influence hepatic lipid metabolism and physiological responses of other organs, including the heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake of the omega-6 PUFA linoleic acid and lower risk of cardiovascular diseases (CVDs), most likely as a result of lower blood cholesterol concentration. Current evidence suggests that increasing intake of arachidonic acid (up to 1500 mg/day) has no adverse effect on platelet aggregation and blood clotting, immune function and markers of inflammation, but may benefit muscle and cognitive performance. Many studies show that higher intakes of omega-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including CVDs. This is because of the multiple molecular and cellular actions of EPA and DHA. Intervention trials using EPA + DHA indicate benefit on CVD mortality and a significant inverse linear dose–response relationship has been found between EPA + DHA intake and CVD outcomes. In addition to their antioxidant and anti-inflammatory roles, omega-3 fatty acids are considered to regulate platelet homeostasis and lower risk of thrombosis, which together indicate their potential use in COVID-19 therapy.

Nutrients. 2021 Jul; 13(7): 2421.

Published online 2021 Jul 15. doi: 10.3390/nu13072421

Vitamin D and Human Health


Vitamin D is currently one of the hottest topics in research and clinics, as well as in everyday life. Over the past decades, scientists gathered overwhelming evidence indicating that the observed global vitamin D deficiency not only has a negative impact on human skeletal system, but also facilitates development and progression of multiple disease of civilization, including cardiovascular diseases, diabetes, autoimmune disease, and cancer. This Special Issue, entitled “Vitamin D and Human Health”, summarizes recent advances in our understanding of pleiotropic activity of vitamin D in the form of eight comprehensive reviews. Furthermore, eight research papers provide new insight into vitamin D research and highlight new directions.

Int J Mol Sci. 2019 Jan; 20(1): 145.

Published online 2019 Jan 3. doi: 10.3390/ijms20010145

Anxiolytic-like effect of Griffonia simplicifolia Baill. seedextract in rats


The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in mood disorders, no scientific evidence has been provided till now. For this reason the aim of our study was to investigate the effect of Griffonia simplicifolia seed extract on anxiety behaviour. Griffonia simplicifolia seed extract, dosed at 1, 5, 10 and 25 mg/kg, was orallyadministered in rats which were submitted to the dark-light test and open field test, 60 min after the treatment. In the dark-light test, the administration of the extract at the doses of 10 and 25 mg/kg was able to significantly increase the time spent in the light compartment (P<0.05). In the open field test,the extract dosed at 5, 10 and 25 mg/kg induced an anti-tigmotactic effect, as indicated by a significant increase of time spent in the central area of the open field (P<0.01). In conclusion these findings indicate that Griffonia simplicifolia seed extract exerts anxiolytic-like effect in rats and suggest its potential usefulness for the treatment of anxiety in humans.

G Carnevale 1, V Di Viesti, M Zavatti, P Zanoli

PMID: 21353511

DOI: 10.1016/j.phymed.2011.01.016

Why do we take better care of plants than ourselves?

Listen to this horticulturalist explain the care and attention that is needed to grow commercial plants, and then question why we don’t afford ourselves the same level of care.



INTRODUCTION. Knee osteoarthrosis (KO) among the adult populationoften leads to permanent disability, a sharp decrease in the quality of life,and chronic use of analgesics. At the same time, according to the clinicalguidelines of the Russian Rheumatology Association for osteoarthrosistreatment, hyaluronic acid medications are included in the list recommended forKO, and they are particularly effective at stages I-II of the disease.

AIM. Evaluation of the efficiency of the dietarysupplement B-Luron for KO patients within 12 weeks therapy.

MATERIAL AND METHODS. A total of 70 patients withstage I-II deforming osteoarthrosis (DOA) were followed up, consecutivelyincluded in the study from December 14, 2021 to January 31, 2022, for anaverage of 90 days (3 months).

RESULTS AND DISCUSSION. The efficiency of B-Luron forI-II DOA stages was shown: a statistically significant decrease in the level ofpain in knee joints, an improvement in the function of the joint were foundcompared to the initial state. The analysis of objective data showed a positivetrend in ultrasound parameters and MRI features of joint inflammation and adecrease in the need for analgesics within 12 weeks.

CONCLUSION. In a prospective randomized clinical trial with70 knee DOA patients as a part of the combination therapy (12 weeks use) withnon-steroidal anti-inflammatory drugs, B-Luron showed its efficiency for stagesI-II of the disease; there was a positive trend in ultrasound parameters andMRI signs of inflammation in the joints as well as a decrease in the need fornon-steroidal anti-inflammatory drug use.

For citation: UlyanovV.Yu., Romakina N.A., Kalyuta T.Yu., Yurkovets A.A., Fedonnikov A.S. Complexuse of B-Luron Supplement in Knee Osteorathrosis: A Prospective RandomizedStudy. Bulletin of Rehabilitation Medicine. 2022; 21 (6): 68-77.


Introduction. The non specificity of the clinical manifestations of the initial stage of non-alcoholic fatty liver disease (NAFLD) - the stage of steatos is, is the reason for the untimely correction and progression of this disease.

Aim. The aim of the study was to conduct a randomised open comparative study to determine the effectiveness of the use of the food supplement FanDetox as a source of organic compounds in liver function disorders. Material and methods. This study was a single-center randomised open one and included the study of the possibility ofusing the herbal product FanDetox in the complex therapy of NAFLD in patients aged 18 to 75 years with a verified diagnosis of obesity and the presence of signs of steatohepatos is, against the background of basic therapy with Carsil Forte. The study was conducted with the involvement of 68 people matched by sex and age, 34 of whom made up the main observation group, whose participants took the study product 1 sachet 2 times a day after meals, in the form of a suspension obtained after mixing the powder in 100 ml of water. The rest 34 patients made up the comparison group. Carsil Forte was chosen as a background drug for both groups. The duration of therapy for each study participant was 3 months. The follow-up process included patient visits with a detailed medical history, therapeutic examination, and laboratory and instrumental examinations.Statistical analysis was carried out using the IBM SPSS Statistics 23 program. Results and discussion. As a result, an improvement in the subjective well-being of patients, a decrease in the echoscopic manifestations of fatty hepatosis, a decrease in the longitudinal size of the liver, a decrease in the manifestations of the cytolysis syndrome and bilirubin levels, as well as a significant positive dynamics of the lipid spectrum in the blood of patients who received complex therapy, including the use of the FanDetox biologically active additive, compared with the comparison group undergoing therapy with the background drug Carsil Forte, were shown.

Conclusion. It has been established that taking the food supplement FanDetox helps to reduce the manifestations of fatty hepatosis, reduce the longitudinal size of the liver, blood biochemistry indicators and the general well-being of patients.

In: The Bulletin of Contemporary Clinical Medicine, Issue: 2, Volume: 15, Page: 60-66

Probiotic BSH Activity and Anti-Obesity Potential of Lactobacillus plantarum Strain TCI378 Isolated from Korean Kimchi


Lactobacillus (Lab.) is a human probiotic beneficial for the prevention and improvement of disease, yet properties of different Lab. strains are diverse. To obtain a Lab. strain that possesses greater potential against gastrointestinal dysfunction, we isolated Lactobacillus plantarum TCI378 (TCI378) from naturally fermented Korean kimchi. TCI378 has shown potential as probiotic since it can survive at pH 3.0 and in the presence of 0.3% bile acid. The bile salt hydrolase activity of TCI378 was shown by formation of opaque granular white colonies on solid de Man Rogosa Sharpe (MRS) medium supplemented with taurodeoxycholic acid, and its cholesterol-lowering ability in MRS medium supplemented with cholesterol. The metabolites of TCI378 from liquid culture in MRS medium prevented emulsification of bile salts. Moreover, both the metabolites of TCI378 and the dead bacteria reduced oil droplet accumulation in 3T3-L1, as detected by Oil red O staining. The expressions of adipocyte-specific genes perilipin 1 and glucose transporter type 4 were suppressed by the metabolites of TCI378, indicating TCI378 may have anti-obesity effects in adipocytes. These in vitro data show the potential of the prophylactic applications of TCI378 and its metabolites for reducing fat and lowering cholesterol.

Prev Nutr Food Sci. 2019 Dec; 24(4): 434–441.

Published online 2019 Dec 31. doi: 10.3746/pnf.2019.24.4.434

A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings


Since ancient times, licorice, the root of Glycyrrhiza glabra, has been known to have a wide spectrum of therapeutic effects. Glycyrrhizin is cleaved to glycyrrhizic acid, which is subsequently converted to glycyrrhetic acid by human intestinal microflora. Glycyrrhetic acid is a potent inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) and performs a range of corticosteroid-like activities. The pharmacologic effects of licorice contribute to its anti-inflammatory, antioxidative, anti-allergenic, and antimicrobial properties. Licorice has been used to treat liver disease, gastrointestinal disorders, oral disease, and various skin disorders and has been used in gum, candy, herbs, alcoholic beverages, and food supplements. Licorice and its extracts, especially glycyrrhizin, can be taken orally, through the skin (in the form of gels and oils), and intravenously. Licorice demonstrates mineralocorticoid-like activity not only by inhibiting 11β-HSD2, but also by binding to a mineralocorticoid receptor, leading to potentially adverse risks of mineralocorticoid-like overactivity. Chronic use of licorice can lead to hypokalemia and hypertension, and some people are more sensitive to licorice exposure. Based on clinical trials, this review sumarises the positive effects of licorice and other reported side effects.

PMID: 31874059

DOI: 10.1089/jmf.2019.4459


Stop illness in its tracks by nourishing your body with clean, wholesome ingredients and bioavailable water.

Dr. Otto Warburg was born in 1883 in Freiburg, Germany. He studied under Emil Fischer in Berlin, until receiving a Doctorate in Chemistry in 1906. By the age of twenty-eight, he also received a Doctorate in Medicine and was awarded the Nobel Prize in Physiology (Medicine) in 1931.  

He spent a significant portion of his life studying oxygen consumption and fermentation. In 1928, he released the well-known paper, “The Chemical Constitution of Respiration Ferment”, where he differentiates the energy consumption between regular body cells and cancer cells. In his paper, Warburg highlights that regular body cells acquire energy through oxygen, making them obligate aerobes (for those of us who don’t have a background in science – that means they require oxygen to survive). Whereas cancer cells can split glucose into lactic acid through the process of fermentation to survive, making them partial anaerobes (meaning they don’t need oxygen to survive).

He suggested that cancer cells “live in hypoxic, very low oxygen, and acidic conditions and derive energy from sugars by fermenting them the way yeast does”. As cancer progresses, the body becomes more and more acidic as its pH drops below 7.35. His discoveries were revolutionary for their time, and contributed greatly to what we know about cancer today.

Unfortunately, most of the foods that people consume today are full of sugar and preservatives– which contribute to the acidity levels in the body. The most alkaline foods are vegetables, as well as some fruits, grains, nuts, and alkaline water. Helping your body neutralise some of its acidity is crucial for maintaining your overall health.

While many years have passed since Warburg’s publications and studies, his discoveries still hold true today.

To maintain your health and keep your body at its best, it is very important to keep your body nourished with fresh, wholesome foods, and hydrated with clean, alkaline water.

Brand, Richard A. “Biographical Sketch: Otto Heinrich Warburg, PhD, MD.”Clinical Orthopaedics and Related Research 468.11 (2010): 2831–2832. PMC. Web.9 May 2017.

Warburg, Otto Heinrich. “The Classic: TheChemical Constitution of Respiration Ferment.” Clinical Orthopaedics and Related Research 468.11 (2010): 2833–2839. PMC. Web. 9 May 2017

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